Accelerated Mammary Tumor Development in Mutant Polyomavirus Middle T Transgenic Mice Expressing Elevated Levels of Either the Shc or Grb2 Adapter Protein

The Grb2 and Shc adapter proteins play critical roles in coupling activated growth factor receptors to several cellular signaling pathways. To assess the role of these molecules in mammary epithelial development and tumorigenesis, we have generated transgenic mice which individually express the Grb2...

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Detalhes bibliográficos
Main Authors: Rauh, Michael J., Blackmore, Valerie, Andrechek, Eran R., Tortorice, Christopher G., Daly, Roger, Lai, Venus Ka-Man, Pawson, Tony, Cardiff, Robert D., Siegel, Peter M., Muller, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC84901/
https://ncbi.nlm.nih.gov/pubmed/10567542
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