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Identification by In Vivo Genomic Footprinting of a Transcriptional Switch Containing NF-κB and Sp1 That Regulates the IκBα Promoter

In unstimulated cells, NF-κB transcription factors are retained in the cytoplasm by inhibitory IκB proteins. Upon stimulation by multiple inducers including cytokines or viruses, IκBα is rapidly phosphorylated and degraded, resulting in the release of NF-κB and the subsequent increase in NF-κB-regul...

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Udgivet i:Mol Cell Biol
Principais autores: Algarté, Michèle, Kwon, Hakju, Génin, Pierre, Hiscott, John
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1999
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84541/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10454561/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.9.6140
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