The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases

To be fully activated at the plasma membrane, Raf-1 must establish two distinct modes of interactions with Ras, one through its Ras-binding domain and the other through its cysteine-rich domain (CRD). The Ras homologue Rap1A is incapable of activating Raf-1 and even antagonizes Ras-dependent activat...

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Bibliographic Details
Main Authors: Okada, Tomoyo, Hu, Chang-Deng, Jin, Tai-Guang, Kariya, Ken-ichi, Yamawaki-Kataoka, Yuriko, Kataoka, Tohru
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC84512/
https://ncbi.nlm.nih.gov/pubmed/10454553
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