The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases

To be fully activated at the plasma membrane, Raf-1 must establish two distinct modes of interactions with Ras, one through its Ras-binding domain and the other through its cysteine-rich domain (CRD). The Ras homologue Rap1A is incapable of activating Raf-1 and even antagonizes Ras-dependent activat...

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Publicado en:	Mol Cell Biol
Autores principales:	Okada, Tomoyo, Hu, Chang-Deng, Jin, Tai-Guang, Kariya, Ken-ichi, Yamawaki-Kataoka, Yuriko, Kataoka, Tohru
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1999
Materias:	Cell Growth and Development
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84512/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10454553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.9.6057
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