The RafC1 Cysteine-Rich Domain Contains Multiple Distinct Regulatory Epitopes Which Control Ras-Dependent Raf Activation

Activation of c-Raf-1 (referred to as Raf) by Ras is a pivotal step in mitogenic signaling. Raf activation is initiated by binding of Ras to the regulatory N terminus of Raf. While Ras binding to residues 51 to 131 is well understood, the role of the RafC1 cysteine-rich domain comprising residues 13...

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Autores principales: Daub, Martina, Jöckel, Johannes, Quack, Thomas, Weber, Christoph K., Schmitz, Frank, Rapp, Ulf R., Wittinghofer, Alfred, Block, Christoph
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1998
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC109253/
https://ncbi.nlm.nih.gov/pubmed/9774683
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