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The RafC1 Cysteine-Rich Domain Contains Multiple Distinct Regulatory Epitopes Which Control Ras-Dependent Raf Activation

Activation of c-Raf-1 (referred to as Raf) by Ras is a pivotal step in mitogenic signaling. Raf activation is initiated by binding of Ras to the regulatory N terminus of Raf. While Ras binding to residues 51 to 131 is well understood, the role of the RafC1 cysteine-rich domain comprising residues 13...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Daub, Martina, Jöckel, Johannes, Quack, Thomas, Weber, Christoph K., Schmitz, Frank, Rapp, Ulf R., Wittinghofer, Alfred, Block, Christoph
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 1998
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC109253/
https://ncbi.nlm.nih.gov/pubmed/9774683
Tagiau: Ychwanegu Tag
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