The RafC1 Cysteine-Rich Domain Contains Multiple Distinct Regulatory Epitopes Which Control Ras-Dependent Raf Activation

Activation of c-Raf-1 (referred to as Raf) by Ras is a pivotal step in mitogenic signaling. Raf activation is initiated by binding of Ras to the regulatory N terminus of Raf. While Ras binding to residues 51 to 131 is well understood, the role of the RafC1 cysteine-rich domain comprising residues 13...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Daub, Martina, Jöckel, Johannes, Quack, Thomas, Weber, Christoph K., Schmitz, Frank, Rapp, Ulf R., Wittinghofer, Alfred, Block, Christoph
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1998
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109253/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9774683/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.11.6698
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