A Novel Role in DNA Metabolism for the Binding of Fen1/Rad27 to PCNA and Implications for Genetic Risk

Fen1/Rad27 nuclease activity, which is important in DNA metabolism, is stimulated by proliferating cell nuclear antigen (PCNA) in vitro. The in vivo role of the PCNA interaction was investigated in the yeast Rad27. A nuclease-defective rad27 mutation had a dominant-negative effect that was suppresse...

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Main Authors: Gary, Ronald, Park, Min S., Nolan, John P., Cornelius, Helen L., Kozyreva, Olga G., Tran, Hiep T., Lobachev, Kirill S., Resnick, Michael A., Gordenin, Dmitry A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1999
Assuntos:
DNA Dynamics and Chromosome Structure
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC84380/
https://ncbi.nlm.nih.gov/pubmed/10409728
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