Atm Inactivation Results in Aberrant Telomere Clustering during Meiotic Prophase

A-T (ataxia telangiectasia) individuals frequently display gonadal atrophy, and Atm(−/−) mice show spermatogenic failure due to arrest at prophase of meiosis I. Chromosomal movements take place during meiotic prophase, with telomeres congregating on the nuclear envelope to transiently form a cluster...

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Bibliographic Details
Main Authors: Pandita, Tej K., Westphal, Christoph H., Anger, Melanie, Sawant, Satin G., Geard, Charles R., Pandita, Raj K., Scherthan, Harry
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC84352/
https://ncbi.nlm.nih.gov/pubmed/10373558
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