Induction of p21(WAF1/CIP1) and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16(INK4a)

The tumor suppressor p16(INK4a) inhibits cyclin-dependent kinases 4 and 6. This activates the retinoblastoma protein (pRB) and, through incompletely understood events, arrests the cell division cycle. To permit biochemical analysis of the arrest, we generated U2-OS osteogenic sarcoma cell clones in...

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Autors principals: Mitra, Jayashree, Dai, Charlotte Y., Somasundaram, Kumaravel, El-Deiry, Wafik S., Satyamoorthy, Kapaettu, Herlyn, Meenhard, Enders, Greg H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC84249/
https://ncbi.nlm.nih.gov/pubmed/10207115
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