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Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1)
Although caspase-2 represents the most conserved caspase across species and was the second caspase identified, its precise function remains enigmatic. In several cell types we show that knockdown of caspase-2 specifically impaired DNA damage-induced p21 expression, whereas overexpression of a caspas...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3172119/ https://ncbi.nlm.nih.gov/pubmed/21475302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.34 |
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