Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1)

Although caspase-2 represents the most conserved caspase across species and was the second caspase identified, its precise function remains enigmatic. In several cell types we show that knockdown of caspase-2 specifically impaired DNA damage-induced p21 expression, whereas overexpression of a caspas...

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Bibliografske podrobnosti
Main Authors: Sohn, D, Budach, W, Jänicke, R U
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172119/
https://ncbi.nlm.nih.gov/pubmed/21475302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.34
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