p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage

Decitabine (DAC) and 5-azacitidine have recently been approved for the treatment of myelodysplastic syndrome. Thepharm acodynamic effects of DAC and 5-azacitidine outsidethe ir known activity as inhibitors of DNA methyltransferases (DNMTs) require further investigation. The purpose of this study was...

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Hlavní autoři: Jiemjit, A, Fandy, TE, Carraway, H, Bailey, KA, Baylin, S, Herman, JG, Gore, SD
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471157/
https://ncbi.nlm.nih.gov/pubmed/18223691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1211018
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