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Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity

The product of the retinoblastoma susceptibility gene, pRB, is a nuclear phosphoprotein that controls cell growth by binding to and suppressing the activities of transcription factors such as the E2F family. Transactivation activity is inhibited when E2F is bound to hypophosphorylated pRB and releas...

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Hlavní autoři: Brown, Vivette D., Phillips, Robert A., Gallie, Brenda L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC84119/
https://ncbi.nlm.nih.gov/pubmed/10207050
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