Mutator Phenotypes Conferred by MLH1 Overexpression and by Heterozygosity for mlh1 Mutations

Loss of DNA mismatch repair due to mutation or diminished expression of the MLH1 gene is associated with genome instability and cancer. In this study, we used a yeast model system to examine three circumstances relevant to modulation of MLH1 function. First, overexpression of wild-type MLH1 was foun...

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Bibliographic Details
Main Authors: Shcherbakova, Polina V., Kunkel, Thomas A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC84111/
https://ncbi.nlm.nih.gov/pubmed/10082584
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