Cell Growth Inhibition by Farnesyltransferase Inhibitors Is Mediated by Gain of Geranylgeranylated RhoB

Recent results have shown that the ability of farnesyltransferase inhibitors (FTIs) to inhibit malignant cell transformation and Ras prenylation can be separated. We proposed previously that farnesylated Rho proteins are important targets for alternation by FTIs, based on studies of RhoB (the FTI-Rh...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Du, Wei, Lebowitz, Peter F., Prendergast, George C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1999
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83976/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022870/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.1831
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