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Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

The JNK pathway modulates AP-1 activity. While in some cells it may have proliferative and protective roles, in neuronal cells it is involved in apoptosis in response to stress or withdrawal of survival signals. To understand how JNK activation leads to apoptosis, we used PC12 cells and primary neur...

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Autori principali: Le-Niculescu, Helen, Bonfoco, Emanuela, Kasuya, Yoshitoshi, Claret, Francois-Xavier, Green, Douglas R., Karin, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC83932/
https://ncbi.nlm.nih.gov/pubmed/9858598
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