Oncolytic Poxvirus Armed with Fas Ligand Leads to Induction of Cellular Fas Receptor and Selective Viral Replication in FasR Negative Cancer

The TNF superfamily members including Fas ligand and TRAIL have been studied extensively for cancer therapy, including as components of gene therapy. We examined the use of FasL expression to achieve tumor selective replication of an oncolytic poxvirus (vFasL) and explored its biology and therapeuti...

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Detalhes bibliográficos
Main Authors: Sathaiah, Magesh, Thirunavukkarasu, Pragatheeshwar, O’Malley, Mark E., Kavanagh, Maihgan A., Ravindranathan, Roshni, Austin, Frances, Guo, Z. Sheng, Bartlett, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288301/
https://ncbi.nlm.nih.gov/pubmed/22116377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2011.77
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