CXCL11-Armed oncolytic poxvirus elicits potent antitumor immunity and shows enhanced therapeutic efficacy

We have armed a tumor-selective oncolytic vaccinia virus (vvDD) with the chemokine (CK) CXCL11, in order to enhance its ability to attract CXCR3(+) antitumor CTLs and possibly NK cells to the tumor microenvironment (TME) and improve its therapeutic efficacy. As expected, vvDD-CXCL11 attracted high n...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Liu, Zuqiang, Ravindranathan, Roshni, Li, Jun, Kalinski, Pawel, Guo, Z. Sheng, Bartlett, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839379/
https://ncbi.nlm.nih.gov/pubmed/27141352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1091554
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