Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade

Oncolytic immunotherapy is a promising novel therapeutic for cancer, and further preclinical studies may maximize its therapeutic efficacy. In this study, we construct a novel oncolytic vaccinia virus (VV) expressing a superagoinst IL-15, a fusion protein of IL-15 and IL-15Ralpha. This virus, named...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Kowalsky, Stacy J., Liu, Zuqiang, Feist, Mathilde, Berkey, Sara E., Ma, Congrong, Ravindranathan, Roshni, Dai, Enyong, Roy, Edward J., Guo, Zong Sheng, Bartlett, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171074/
https://ncbi.nlm.nih.gov/pubmed/30064894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.07.013
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