p21(Waf1/Cip1) Inhibition of Cyclin E/Cdk2 Activity Prevents Endoreduplication after Mitotic Spindle Disruption

During a normal cell cycle, entry into S phase is dependent on completion of mitosis and subsequent activation of cyclin-dependent kinases (Cdks) in G(1). These events are monitored by checkpoint pathways. Recent studies and data presented herein show that after treatment with microtubule inhibitors...

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Autors principals: Stewart, Zoe A., Leach, Steven D., Pietenpol, Jennifer A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC83879/
https://ncbi.nlm.nih.gov/pubmed/9858545
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