Acute depletion of METTL3 implicates N(6)-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome

RNA N(6)-methyladenosine (m(6)A) modification plays important roles in multiple aspects of RNA regulation. m(6)A is installed cotranscriptionally by the METTL3/14 complex, but its direct roles in RNA processing remain unclear. Here, we investigate the presence of m(6)A in nascent RNA of mouse embryo...

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Vydáno v:Genome Res
Hlavní autoři: Wei, Guifeng, Almeida, Mafalda, Pintacuda, Greta, Coker, Heather, Bowness, Joseph S., Ule, Jernej, Brockdorff, Neil
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327914/
https://ncbi.nlm.nih.gov/pubmed/34131006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.271635.120
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