Mechanical Ventilation Exacerbates Poly (I:C) Induced Acute Lung Injury: Central Role for Caspase-11 and Gut-Lung Axis

BACKGROUND: The mechanisms by which moderate tidal volume ventilation (MTV) exacerbates preexisting lung injury are unclear. We hypothesized that systemic endotoxemia via the gut-lung axis would lead to non-canonical and canonical inflammasome activation and pyroptosis in a two-hit model involving p...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Jin, Shuqing, Ding, Xibing, Yang, Chenxuan, Li, Wenbo, Deng, Meihong, Liao, Hong, Lv, Xin, Pitt, Bruce R., Billiar, Timothy R., Zhang, Li-Ming, Li, Quan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327178/
https://ncbi.nlm.nih.gov/pubmed/34349759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.693874
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