Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1–αvβ5 integrin pathway in TLR4-mediated inflammation and injury

BACKGROUND: High tidal volume ventilation of healthy lungs or exacerbation of existing acute lung injury (ALI) by more moderate mechanical ventilation (MTV) produces ventilator-induced lung injury. It is less clear whether extrapulmonary sepsis sensitizes the lung to MTV. METHODS: We used a two-hit...

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發表在:Crit Care
Main Authors: Ding, Xibing, Tong, Yao, Jin, Shuqing, Chen, Zhixia, Li, Tunliang, Billiar, Timothy R., Pitt, Bruce R., Li, Quan, Zhang, Li-Ming
格式: Artigo
語言:Inglês
出版: BioMed Central 2018
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Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240278/
https://ncbi.nlm.nih.gov/pubmed/30445996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-018-2237-0
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