Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway

The presence of gastric cancer stem cells (GCSCs) marks the onset of gastric carcinoma. The sonic hedgehog (SHH) pathway plays a vital role in the maintenance of GCSC characteristics. Apatinib has been approved in China for advanced gastric cancer (GC) treatment. However, whether apatinib can target...

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Vydáno v:Front Cell Dev Biol
Hlavní autoři: Cao, Wanshuang, Li, Yuan, Sun, Hongliang, Yang, Chenying, Zhu, Jianyun, Xie, Chunfeng, Li, Xiaoting, Wu, Jieshu, Geng, Shanshan, Wang, Lu, Sun, Liangfei, Geng, Guozhu, Han, Hongyu, Zhong, Caiyun
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8326764/
https://ncbi.nlm.nih.gov/pubmed/34350176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.679806
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