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RAG deficiencies: Recent advances in disease pathogenesis and novel therapeutic approaches
The RAG1 and RAG2 proteins initiate the process of V(D)J recombination and therefore play an essential role in adaptive immunity. While null mutations in the RAG genes cause severe combined immune deficiency with lack of T and B cells (T(−)B(−) SCID) and susceptibility to life-threatening, early-ons...
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| Publié dans: | Eur J Immunol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8325549/ https://ncbi.nlm.nih.gov/pubmed/33682138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.202048880 |
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