Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries

Germ cells form the basis for sexual reproduction by producing gametes. In ovaries, primordial germ cells exit the cell cycle and the pluripotency-associated state, differentiate into oogonia, and initiate meiosis. Despite the importance of germ cell differentiation for sexual reproduction, signalin...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Le Rolle, Morgane, Massa, Filippo, Siggers, Pam, Turchi, Laurent, Loubat, Agnès, Koo, Bon-Kyoung, Clevers, Hans, Greenfield, Andy, Schedl, Andreas, Chaboissier, Marie-Christine, Chassot, Anne-Amandine
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325354/
https://ncbi.nlm.nih.gov/pubmed/34301885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023376118
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