Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries

Germ cells form the basis for sexual reproduction by producing gametes. In ovaries, primordial germ cells exit the cell cycle and the pluripotency-associated state, differentiate into oogonia, and initiate meiosis. Despite the importance of germ cell differentiation for sexual reproduction, signalin...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Le Rolle, Morgane, Massa, Filippo, Siggers, Pam, Turchi, Laurent, Loubat, Agnès, Koo, Bon-Kyoung, Clevers, Hans, Greenfield, Andy, Schedl, Andreas, Chaboissier, Marie-Christine, Chassot, Anne-Amandine
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325354/
https://ncbi.nlm.nih.gov/pubmed/34301885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023376118
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