Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries

Germ cells form the basis for sexual reproduction by producing gametes. In ovaries, primordial germ cells exit the cell cycle and the pluripotency-associated state, differentiate into oogonia, and initiate meiosis. Despite the importance of germ cell differentiation for sexual reproduction, signalin...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Le Rolle, Morgane, Massa, Filippo, Siggers, Pam, Turchi, Laurent, Loubat, Agnès, Koo, Bon-Kyoung, Clevers, Hans, Greenfield, Andy, Schedl, Andreas, Chaboissier, Marie-Christine, Chassot, Anne-Amandine
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325354/
https://ncbi.nlm.nih.gov/pubmed/34301885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023376118
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