Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries

Germ cells form the basis for sexual reproduction by producing gametes. In ovaries, primordial germ cells exit the cell cycle and the pluripotency-associated state, differentiate into oogonia, and initiate meiosis. Despite the importance of germ cell differentiation for sexual reproduction, signalin...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Le Rolle, Morgane, Massa, Filippo, Siggers, Pam, Turchi, Laurent, Loubat, Agnès, Koo, Bon-Kyoung, Clevers, Hans, Greenfield, Andy, Schedl, Andreas, Chaboissier, Marie-Christine, Chassot, Anne-Amandine
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325354/
https://ncbi.nlm.nih.gov/pubmed/34301885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023376118
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