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Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington’s disease
Mitochondrial dysfunction is found in the brain and peripheral tissues of patients diagnosed with Huntington’s disease (HD), an irreversible neurodegenerative disease of which aging is a major risk factor. Mitochondrial function is encoded by not only nuclear DNA but also DNA within mitochondria (mt...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8325154/ https://ncbi.nlm.nih.gov/pubmed/34301881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014610118 |
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