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Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington’s disease
Mitochondrial dysfunction is found in the brain and peripheral tissues of patients diagnosed with Huntington’s disease (HD), an irreversible neurodegenerative disease of which aging is a major risk factor. Mitochondrial function is encoded by not only nuclear DNA but also DNA within mitochondria (mt...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8325154/ https://ncbi.nlm.nih.gov/pubmed/34301881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014610118 |
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