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Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals

A majority of mitochondrial DNA (mtDNA) mutations reported to be implicated in diseases are heteroplasmic, a status with coexisting mtDNA variants in a single cell. Quantifying the prevalence of mitochondrial heteroplasmy and its pathogenic effect in healthy individuals could further our understandi...

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Main Authors: Ye, Kaixiong, Lu, Jian, Ma, Fei, Keinan, Alon, Gu, Zhenglong
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115537/
https://ncbi.nlm.nih.gov/pubmed/25002485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403521111
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