Reinvestigation of the structure-activity relationships of isoniazid

Isoniazid (INH) remains a cornerstone for treatment of drug susceptible tuberculosis (TB), yet the quantitative structure-activity relationships for INH are not well documented in the literature. In this paper, we have evaluated a systematic series of INH analogs against contemporary Mycobacterium t...

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Publicat a:Tuberculosis (Edinb)
Autors principals: Hegde, Pooja, Boshoff, Helena I.M., Rusman, Yudi, Aragaw, Wassihun Wedajo, Salomon, Christine E., Dick, Thomas, Aldrich, Courtney C.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324568/
https://ncbi.nlm.nih.gov/pubmed/34116482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2021.102100
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