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Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis
A series of 2-aminothiazoles was synthesized based on a HTS scaffold from a whole-cell screen against Mycobacterium tuberculosis (Mtb). The SAR shows the central thiazole moiety and the 2-pyridyl moiety at C-4 of the thiazole are intolerant to modification. However, the N-2 position of the aminothia...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3816974/ https://ncbi.nlm.nih.gov/pubmed/24075144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.08.048 |
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