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Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis

MbtA catalyzes the first committed biosynthetic step of the mycobactins, which are important virulence factors associated with iron acquisition in Mycobacterium tuberculosis. MbtA is a validated therapeutic target for antitubercular drug development. 5′-O-[N-(salicyl)sulfamoyl]adenosine (1) is a bis...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Nelson, Kathryn M., Viswanathan, Kishore, Dawadi, Surendra, Duckworth, Benjamin P., Boshoff, Helena I., Barry, Clifton E., Aldrich, Courtney C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667731/
https://ncbi.nlm.nih.gov/pubmed/26110337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00391
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