Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis

MbtA catalyzes the first committed biosynthetic step of the mycobactins, which are important virulence factors associated with iron acquisition in Mycobacterium tuberculosis. MbtA is a validated therapeutic target for antitubercular drug development. 5′-O-[N-(salicyl)sulfamoyl]adenosine (1) is a bis...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Nelson, Kathryn M., Viswanathan, Kishore, Dawadi, Surendra, Duckworth, Benjamin P., Boshoff, Helena I., Barry, Clifton E., Aldrich, Courtney C.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667731/
https://ncbi.nlm.nih.gov/pubmed/26110337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00391
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