A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope

Glypican 2 (GPC2) is a MYCN-regulated, differentially expressed cell-surface oncoprotein and target for immune-based therapies in neuroblastoma. Here, we build on GPC2’s immunotherapeutic attributes by finding that it is also a highly expressed, MYCN-driven oncoprotein on small-cell lung cancers (SC...

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Gepubliceerd in:Cell Rep Med
Hoofdauteurs: Raman, Swetha, Buongervino, Samantha N., Lane, Maria V., Zhelev, Doncho V., Zhu, Zhongyu, Cui, Hong, Martinez, Benjamin, Martinez, Daniel, Wang, Yanping, Upton, Kristen, Patel, Khushbu, Rathi, Komal S., Navia, Carmen T., Harmon, Daniel B., Li, Yimei, Pawel, Bruce, Dimitrov, Dimiter S., Maris, John M., Julien, Jean-Philippe, Bosse, Kristopher R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324494/
https://ncbi.nlm.nih.gov/pubmed/34337560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100344
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