Identification of GPC2 as an oncoprotein and candidate immunotherapeutic target in high-risk neuroblastoma

We developed an RNA sequencing-based pipeline to discover differentially expressed cell surface molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target safety and efficacy. Here we show that GPC2 is a strong candidate immunotherapeutic target in this childhood cancer. We d...

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書誌詳細
出版年:Cancer Cell
主要な著者: Bosse, Kristopher R., Raman, Pichai, Zhu, Zhongyu, Lane, Maria, Martinez, Daniel, Heitzeneder, Sabine, Rathi, Komal S., Kendsersky, Nathan M., Randall, Michael, Donovan, Laura, Morrissy, Sorana, Sussman, Robyn T., Zhelev, Doncho V., Feng, Yang, Wang, Yanping, Hwang, Jennifer, Garcia, Gonzalo Lopez, Harenza, Jo Lynne, Wei, Jun, Pawel, Bruce, Bhatti, Tricia, Santi, Mariarita, Ganguly, Arupa, Khan, Javed, Marra, Marco A., Taylor, Michael D., Dimitrov, Dimiter S., Mackall, Crystal, Maris, John M.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600520/
https://ncbi.nlm.nih.gov/pubmed/28898695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.08.003
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