Identification of GPC2 as an oncoprotein and candidate immunotherapeutic target in high-risk neuroblastoma

We developed an RNA sequencing-based pipeline to discover differentially expressed cell surface molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target safety and efficacy. Here we show that GPC2 is a strong candidate immunotherapeutic target in this childhood cancer. We d...

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Vydáno v:Cancer Cell
Hlavní autoři: Bosse, Kristopher R., Raman, Pichai, Zhu, Zhongyu, Lane, Maria, Martinez, Daniel, Heitzeneder, Sabine, Rathi, Komal S., Kendsersky, Nathan M., Randall, Michael, Donovan, Laura, Morrissy, Sorana, Sussman, Robyn T., Zhelev, Doncho V., Feng, Yang, Wang, Yanping, Hwang, Jennifer, Garcia, Gonzalo Lopez, Harenza, Jo Lynne, Wei, Jun, Pawel, Bruce, Bhatti, Tricia, Santi, Mariarita, Ganguly, Arupa, Khan, Javed, Marra, Marco A., Taylor, Michael D., Dimitrov, Dimiter S., Mackall, Crystal, Maris, John M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600520/
https://ncbi.nlm.nih.gov/pubmed/28898695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.08.003
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