IMMU-04. DEVELOPMENT OF GPC2-DIRECTED CHIMERIC ANTIGEN RECEPTOR THERAPY FOR PEDIATRIC BRAIN TUMORS WITH IN VITRO TRANSCRIBED mRNA

The recent identification of glypican-2 (GPC2) as a cell surface oncoprotein in neuroblastoma, high grade glioma (HGG), and medulloblastoma provides the opportunity for the development of targeted immunotherapy. We hypothesized that chimeric antigen receptor (CAR) T cell therapy directed against GPC...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Foster, Jessica B, Griffin, Crystal, Stern, Allison, Brimley, Cameron, Lane, Maria, Buongervino, Samantha, Dimitrov, Dimiter S, Barrett, David M, Resnick, Adam C, Maris, John M, Bosse, Kristopher R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Immunology/Immunotherapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477251/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.125
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