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Biosynthetic Proteases that Catalyze the Macrocyclization of Ribosomally Synthesized Linear Peptides

Circular peptides have long been sought after as scaffolds for drug design as they demonstrate protein-like properties in the context of small, constrained peptides. Traditional routes towards the production of cyclic peptides rely on synthesis or semi-synthetic methods, which restrict their use as...

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Publicat a:Biochemistry
Autors principals: Ongpipattanakul, Chayanid, Nair, Satish K.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324308/
https://ncbi.nlm.nih.gov/pubmed/29553721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00114
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