Early developmental asymmetries in cell lineage trees in living individuals

Mosaic mutations can be used to track cell lineages in humans. We used cell cloning to analyze embryonic cell lineages in two living individuals and a postmortem human specimen. Of ten reconstructed post-zygotic divisions, none resulted in balanced contributions of daughter lineages to tissues. In b...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Fasching, Liana, Jang, Yeongjun, Tomasi, Simone, Schreiner, Jeremy, Tomasini, Livia, Brady, Melanie, Bae, Taejeong, Sarangi, Vivekananda, Vasmatzis, Nikolaos, Wang, Yifan, Szekely, Anna, Fernandez, Thomas V., Leckman, James F., Abyzov, Alexej, Vaccarino, Flora M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324008/
https://ncbi.nlm.nih.gov/pubmed/33737484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abe0981
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