Early developmental asymmetries in cell lineage trees in living individuals

Mosaic mutations can be used to track cell lineages in humans. We used cell cloning to analyze embryonic cell lineages in two living individuals and a postmortem human specimen. Of ten reconstructed post-zygotic divisions, none resulted in balanced contributions of daughter lineages to tissues. In b...

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Foilsithe in:Science
Main Authors: Fasching, Liana, Jang, Yeongjun, Tomasi, Simone, Schreiner, Jeremy, Tomasini, Livia, Brady, Melanie, Bae, Taejeong, Sarangi, Vivekananda, Vasmatzis, Nikolaos, Wang, Yifan, Szekely, Anna, Fernandez, Thomas V., Leckman, James F., Abyzov, Alexej, Vaccarino, Flora M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2021
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324008/
https://ncbi.nlm.nih.gov/pubmed/33737484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abe0981
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