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Characterization of the direct pathway in Dyt1 ΔGAG heterozygous knock-in mice and dopamine receptor 1-expressing-cell-specific Dyt1 conditional knockout mice

DYT1 dystonia is a movement disorder mainly caused by a trinucleotide deletion (ΔGAG) in DYT1 (TOR1A), coding for torsinA. DYT1 dystonia patients show trends of decreased striatal ligand-binding activities to dopamine receptors 1 (D1R) and 2 (D2R). Dyt1 ΔGAG knock-in (KI) mice, which have the corres...

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Detalhes bibliográficos
Publicado no:Behav Brain Res
Main Authors: Yokoi, Fumiaki, Chen, Huan-Xin, Oleas, Janneth, Dang, Mai Tu, Xing, Hong, Dexter, Kelly M., Li, Yuqing
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323984/
https://ncbi.nlm.nih.gov/pubmed/34038798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2021.113381
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