Behavioral and Electrophysiological Characterization of Dyt1 Heterozygous Knockout Mice

DYT1 dystonia is an inherited movement disorder caused by mutations in DYT1 (TOR1A), which codes for torsinA. Most of the patients have a trinucleotide deletion (ΔGAG) corresponding to a glutamic acid in the C-terminal region (torsinA(ΔE)). Dyt1 ΔGAG heterozygous knock-in (KI) mice, which mimic ΔGAG...

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Publicado en:PLoS One
Autores principales: Yokoi, Fumiaki, Chen, Huan-Xin, Dang, Mai Tu, Cheetham, Chad C., Campbell, Susan L., Roper, Steven N., Sweatt, J. David, Li, Yuqing
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370625/
https://ncbi.nlm.nih.gov/pubmed/25799505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120916
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