Altered Dendritic Morphology of Purkinje cells in Dyt1 ΔGAG Knock-In and Purkinje Cell-Specific Dyt1 Conditional Knockout Mice

BACKGROUND: DYT1 early-onset generalized dystonia is a neurological movement disorder characterized by involuntary muscle contractions. It is caused by a trinucleotide deletion of a GAG (ΔGAG) in the DYT1 (TOR1A) gene encoding torsinA; the mouse homolog of this gene is Dyt1 (Tor1a). Although structu...

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Lin, Yokoi, Fumiaki, Jin, Yuan-Hu, DeAndrade, Mark P., Hashimoto, Kenji, Standaert, David G., Li, Yuqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066238/
https://ncbi.nlm.nih.gov/pubmed/21479250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018357
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