New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase

[Image: see text] Deoxyhypusine synthase (DHPS) is the primary enzyme responsible for the hypusine modification and, thereby, activation of the eukaryotic translation initiation factor 5A (eIF5A), which is key in regulating the protein translation processes associated with tumor proliferation. Altho...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Tanaka, Yuta, Kurasawa, Osamu, Yokota, Akihiro, Klein, Michael G., Saito, Bunnai, Matsumoto, Shigemitsu, Okaniwa, Masanori, Ambrus-Aikelin, Geza, Uchiyama, Noriko, Morishita, Daisuke, Kimura, Hiromichi, Imamura, Shinichi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2020
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323115/
https://ncbi.nlm.nih.gov/pubmed/34345355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00331
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