New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase

[Image: see text] Deoxyhypusine synthase (DHPS) is the primary enzyme responsible for the hypusine modification and, thereby, activation of the eukaryotic translation initiation factor 5A (eIF5A), which is key in regulating the protein translation processes associated with tumor proliferation. Altho...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Principais autores: Tanaka, Yuta, Kurasawa, Osamu, Yokota, Akihiro, Klein, Michael G., Saito, Bunnai, Matsumoto, Shigemitsu, Okaniwa, Masanori, Ambrus-Aikelin, Geza, Uchiyama, Noriko, Morishita, Daisuke, Kimura, Hiromichi, Imamura, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323115/
https://ncbi.nlm.nih.gov/pubmed/34345355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00331
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