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Alternative splicing of BCL-X and implications for treating hematological malignancies

BCL-X is a member of the BCL-2 family. It regulates apoptosis and plays a critical role in hematological malignancies. It is well-known that >90% of human genes undergo alternative splicing. A total of 10 distinct splicing transcripts of the BCL-X gene have been identified, including transcript v...

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Bibliographic Details
Published in:Oncol Lett
Main Authors: Chen, Wanling, Li, Jinggang
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323006/
https://ncbi.nlm.nih.gov/pubmed/34345295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2021.12931
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