Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X

Sequences with the potential to form RNA G-quadruplexes (G4s) are common in mammalian introns, especially in the proximity of the 5′ splice site (5′SS). However, the difficulty of demonstrating that G4s form in pre-mRNA in functional conditions has meant that little is known about their effects or m...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Weldon, Carika, Dacanay, Justine G, Gokhale, Vijay, Boddupally, Peda Venkat L, Behm-Ansmant, Isabelle, Burley, Glenn A, Branlant, Christiane, Hurley, Laurence H, Dominguez, Cyril, Eperon, Ian C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
RNA and RNA-protein complexes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778605/
https://ncbi.nlm.nih.gov/pubmed/29156002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1122
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