A Targeted Oligonucleotide Enhancer of SMN2 Exon 7 Splicing Forms Competing Quadruplex and Protein Complexes in Functional Conditions

The use of oligonucleotides to activate the splicing of selected exons is limited by a poor understanding of the mechanisms affected. A targeted bifunctional oligonucleotide enhancer of splicing (TOES) anneals to SMN2 exon 7 and carries an exonic splicing enhancer (ESE) sequence. We show that it sti...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Smith, Lindsay D., Dickinson, Rachel L., Lucas, Christian M., Cousins, Alex, Malygin, Alexey A., Weldon, Carika, Perrett, Andrew J., Bottrill, Andrew R., Searle, Mark S., Burley, Glenn A., Eperon, Ian C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536295/
https://ncbi.nlm.nih.gov/pubmed/25263560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.051
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados