Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit

Intratumoral heterogeneity in lung cancer is essential for evasion of immune surveillance by tumor cells and establishment of immunosuppression. Gathering data reveal that circular RNAs (circRNAs), play a role in the pathogenesis and progression of lung cancer. Particularly Kras-driven circRNA signa...

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Pubblicato in:Sci Rep
Autori principali: Katopodi, Theodora, Petanidis, Savvas, Domvri, Kalliopi, Zarogoulidis, Paul, Anestakis, Doxakis, Charalampidis, Charalampos, Tsavlis, Drosos, Bai, Chong, Huang, Haidong, Freitag, Lutz, Hohenforst-Schmidt, Wolfgang, Matthaios, Dimitris, Porpodis, Konstantinos
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322174/
https://ncbi.nlm.nih.gov/pubmed/34326381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94671-x
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