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AB059. Mutant KRAS cells release tumor specific exosomes that create an immunosuppressive phenotype in lung tumor microenvironment
BACKGROUND: To investigate whether KRAS-secreted exosomal RNAs contribute to metastatic related-EMT phenotype, and their association with the hypoxic immunosuppressive phenotype in lung carcinoma. METHODS: Lung cancer patient tissues and mice were used for exosome isolation. Exosomal molecular chara...
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| Yayımlandı: | Ann Transl Med |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
AME Publishing Company
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5159380/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2016.AB059 |
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