AB059. Mutant KRAS cells release tumor specific exosomes that create an immunosuppressive phenotype in lung tumor microenvironment

BACKGROUND: To investigate whether KRAS-secreted exosomal RNAs contribute to metastatic related-EMT phenotype, and their association with the hypoxic immunosuppressive phenotype in lung carcinoma. METHODS: Lung cancer patient tissues and mice were used for exosome isolation. Exosomal molecular chara...

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Publicado en:Ann Transl Med
Autores principales: Petanidis, Savvas, Domvri, Kalliopi, Nikolaos, Zogas, Zarogoulidis, Paul, Kioseoglou, Efrosini, Anestakis, Doxakis, Zarogoulidis, Konstantinos, Salifoglou, Athanasios
Formato: Artigo
Lenguaje:Inglês
Publicado: AME Publishing Company 2016
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Abstract
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159380/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2016.AB059
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